Perceptive Advisors 13F annual report

Perceptive Advisors is an investment fund managing more than $4.14 trillion ran by Joseph Edelman. There are currently 104 companies in Mr. Edelman’s portfolio. The largest investments include Cerevel Therapeutics Hldng I and Amicus Therapeutics Inc, together worth $720 billion.

$4.14 trillion Assets Under Management (AUM)

As of 9th August 2024, Perceptive Advisors’s top holding is 10,794,876 shares of Cerevel Therapeutics Hldng I currently worth over $441 billion and making up 10.7% of the portfolio value. In addition, the fund holds 28,057,456 shares of Amicus Therapeutics Inc worth $278 billion, whose value fell 16.8% in the past six months. The third-largest holding is Arcellx Inc worth $215 billion and the next is Iovance Biotherapeutics Inc worth $208 billion, with 25,933,142 shares owned.

Currently, Perceptive Advisors's portfolio is worth at least $4.14 trillion. The total portfolio value may be much higher due to cash assets that are not publicly disclosed such as fixed income, real estate, or cash equivalents.

Careers at Perceptive Advisors

The Perceptive Advisors office and employees reside in New York, New York. According to the last 13-F report filed with the SEC, Joseph Edelman serves as the Managing Member at Perceptive Advisors.

Recent trades

In the most recent 13F filing, Perceptive Advisors revealed that it had opened a new position in Contineum Therapeutics Inc and bought 1,566,668 shares worth $27.6 billion.

The investment fund also strengthened its position in Iovance Biotherapeutics Inc by buying 6,660,151 additional shares. This makes their stake in Iovance Biotherapeutics Inc total 25,933,142 shares worth $208 billion. Iovance Biotherapeutics Inc soared 54.6% in the past year.

On the other hand, there are companies that Perceptive Advisors is getting rid of from its portfolio. Perceptive Advisors closed its position in Inhibrx on 16th August 2024. It sold the previously owned 4,256,104 shares for $149 billion. Joseph Edelman also disclosed a decreased stake in Arcellx Inc by approximately 0.1%. This leaves the value of the investment at $215 billion and 3,889,739 shares.

One of the largest hedge funds

The two most similar investment funds to Perceptive Advisors are Magnetar and Raymond James Trust N.a. They manage $4.14 trillion and $4.12 trillion respectively.


Joseph Edelman investment strategy

Perceptive Advisors’s portfolio is diversified across 2 sectors. Currently, their heaviest sector is Health Care — making up 58.2% of the total portfolio value. The fund focuses on investments in the United States as 49.0% of the portfolio companies are based in the United States.

The majority of the companies in the fund’s portfolio are small-cap stocks. Stocks with a size of more than $100 million in market cap make up 10% of the total holdings value. On the other hand, large-cap stocks make up only 3.8% of the portfolio. The average market cap of the portfolio companies is close to $4.84 billion.

The complete list of Perceptive Advisors trades based on 13F SEC filings

These positions were updated on August 16th based on the fund’s latest 13F filing. Quickly find out what the most recently closed or increased positions are.

Security Shares Owned Value Allocation
Cerevel Therapeutics Hldng I
No change
10,794,876
$441,402,480,000 10.65%
Amicus Therapeutics Inc
No change
28,057,456
$278,329,964,000 6.72%
Arcellx Inc
1.11%
3,889,739
$214,674,695,000 5.18%
Iovance Biotherapeutics Inc
34.56%
25,933,142
$207,983,798,000 5.02%
Nuvalent Inc
8.42%
2,549,077
$193,372,981,000 4.67%
Inhibrx, Inc.
Closed
4,256,104
$148,793,396,000
Fusion Pharmaceuticals Inc.
Closed
6,825,395
$145,517,421,000
Rhythm Pharmaceuticals Inc.
5.45%
3,446,579
$141,516,534,000 3.42%
Vaxcyte, Inc.
3.63%
1,862,608
$140,645,530,000 3.39%
Soleno Therapeutics Inc
4.24%
3,204,976
$130,763,021,000 3.16%
Intra-Cellular Therapies Inc
62.64%
1,716,407
$117,556,715,000 2.84%
Immatics N.v
76.46%
8,086,159
$93,961,168,000 2.27%
Neurocrine Biosciences, Inc.
19.21%
649,909
$89,472,972,000 2.16%
Apogee Therapeutics Inc
2.20%
2,105,636
$82,856,776,000 2.00%
Madrigal Pharmaceuticals Inc
38.46%
264,600
$74,130,336,000 1.79%
Artivion Inc
4.67%
2,793,703
$71,658,482,000 1.73%
Spyre Therapeutics Inc
18.55%
3,031,018
$71,259,233,000 1.72%
Sarepta Therapeutics Inc
Closed
525,683
$68,054,921,000
Crinetics Pharmaceuticals In
No change
1,476,203
$66,119,132,000 1.60%
Evolus Inc
No change
5,753,798
$62,428,708,000 1.51%
SpringWorks Therapeutics, Inc.
26.94%
1,652,962
$62,267,079,000 1.50%
Cargo Therapeutics Inc
6.82%
3,683,004
$60,474,925,000 1.46%
Astria Therapeutics Inc
No change
6,485,420
$59,017,322,000 1.42%
Natera Inc
30.01%
530,000
$57,393,700,000 1.39%
Verrica Pharmaceuticals Inc
No change
7,099,182
$51,753,037,000 1.25%
Biohaven Ltd
13.90%
1,485,232
$51,552,403,000 1.24%
Immunovant Inc
35.08%
1,923,786
$50,787,950,000 1.23%
Meiragtx Hldgs Plc
No change
11,331,103
$47,667,625,000 1.15%
Protagonist Therapeutics Inc
27.60%
1,268,735
$43,961,668,000 1.06%
Solid Biosciences Inc
No change
6,906,646
$39,160,682,000 0.95%
Celcuity Inc
No change
2,362,279
$38,694,130,000 0.93%
Medtronic Plc
65.68%
490,665
$38,620,242,000 0.93%
Viking Therapeutics Inc
27.43%
721,377
$38,240,195,000 0.92%
Applied Therapeutics, Inc.
No change
8,005,000
$37,383,350,000 0.90%
Axsome Therapeutics Inc
58.46%
459,111
$36,958,436,000 0.89%
Centessa Pharmaceuticals Plc
27.57%
3,933,307
$35,517,762,000 0.86%
Tarsus Pharmaceuticals, Inc.
No change
1,296,416
$35,236,587,000 0.85%
Verona Pharma Plc
35.30%
2,433,725
$35,191,664,000 0.85%
Akero Therapeutics Inc
8.10%
1,499,897
$35,187,584,000 0.85%
Edgewise Therapeutics Inc
19.97%
1,856,417
$33,434,070,000 0.81%
Landos Biopharma Inc
Closed
1,486,991
$31,940,566,000
Acrivon Therapeutics Inc
78.23%
5,360,858
$31,092,976,000 0.75%
Praxis Precision Medicines I
8.69%
750,230
$31,029,513,000 0.75%
Adma Biologics Inc
56.93%
2,771,000
$30,979,780,000 0.75%
BridgeBio Pharma Inc
13.93%
1,215,346
$30,784,714,000 0.74%
Aldeyra Therapeutics Inc
7.94%
9,275,851
$30,703,067,000 0.74%
Treace Med Concepts Inc
Closed
2,304,954
$30,079,650,000
Nautilus Biotechnology Inc
No change
12,594,211
$29,470,453,000 0.71%
Autolus Therapeutics plc
Closed
4,330,745
$27,630,153,000
Contineum Therapeutics Inc
Opened
1,566,668
$27,589,023,000 0.67%
Intuitive Surgical Inc
39.29%
61,800
$27,491,730,000 0.66%
Arvinas Inc
16.89%
1,027,749
$27,358,678,000 0.66%
Rocket Pharmaceuticals Inc
30.79%
1,246,597
$26,839,233,000 0.65%
Disc Medicine Inc
41.12%
553,437
$24,943,406,000 0.60%
LivaNova PLC
48.49%
444,000
$24,340,080,000 0.59%
Cg Oncology Inc
43.74%
733,695
$23,162,751,000 0.56%
Xenon Pharmaceuticals Inc
34.63%
583,256
$22,741,151,000 0.55%
Ocular Therapeutix Inc
No change
3,324,468
$22,739,361,000 0.55%
Pepgen Inc
No change
1,410,438
$22,510,590,000 0.54%
Viridian Therapeutics Inc
55.38%
1,631,828
$21,230,082,000 0.51%
Orchestra Biomed Hldgs Inc
No change
2,545,881
$20,748,930,000 0.50%
Revolution Medicines Inc
Closed
618,885
$19,946,664,000
Abbvie Inc
Closed
106,500
$19,393,650,000
Merus N.V
Opened
300,000
$17,751,000,000 0.43%
Rapport Therapeutics Inc
Opened
748,183
$17,402,737,000 0.42%
Moonlake Immunotherapeutics
Closed
339,012
$17,028,573,000
Tyra Biosciences Inc
50.54%
1,007,367
$16,107,798,000 0.39%
Inhibrx Biosciences Inc
Opened
1,064,026
$15,077,248,000 0.36%
Arcutis Biotherapeutics Inc
107.80%
1,558,500
$14,494,050,000 0.35%
Athira Pharma, Inc.
No change
5,402,964
$14,317,855,000 0.35%
Zymeworks Inc
55.16%
1,667,711
$14,192,221,000 0.34%
Cullinan Therapeutics Inc
Opened
749,916
$13,078,535,000 0.32%
Procept Biorobotics Corp
No change
210,659
$12,869,158,000 0.31%
Insmed Inc
Opened
180,000
$12,060,000,000 0.29%
Bicycle Therapeutics plc
Opened
572,000
$11,577,280,000 0.28%
RAPT Therapeutics, Inc.
Closed
1,223,472
$10,986,779,000
Morphic Hldg Inc
Closed
288,221
$10,145,379,000
Icon Plc
Opened
31,250
$9,795,938,000 0.24%
Tempus Ai Inc
Opened
275,000
$9,625,000,000 0.23%
Arrivent Biopharma Inc
No change
415,000
$7,698,250,000 0.19%
Engene Holdings Inc
19.91%
800,000
$7,544,000,000 0.18%
Ars Pharmaceuticals Inc
No change
867,319
$7,380,885,000 0.18%
Argenx Se
Opened
15,600
$6,708,624,000 0.16%
Allogene Therapeutics Inc
Opened
2,725,000
$6,349,250,000 0.15%
Veru Inc
26.48%
7,063,277
$5,942,335,000 0.14%
Cogent Biosciences, Inc.
Closed
883,333
$5,935,998,000
KalVista Pharmaceuticals Inc
No change
500,000
$5,890,000,000 0.14%
Recursion Pharmaceuticals In
Opened
769,230
$5,769,225,000 0.14%
Immunitybio Inc
Closed
1,052,887
$5,654,003,000
EyePoint Pharmaceuticals Inc
8.59%
640,274
$5,570,384,000 0.13%
Macrogenics Inc
Closed
378,327
$5,568,973,000
Helix Acquisition Corp Ii
No change
500,000
$5,110,000,000 0.12%
Mereo BioPharma Group plc
Opened
1,253,250
$4,511,700,000 0.11%
Cabaletta Bio Inc
65.92%
585,045
$4,376,137,000 0.11%
Establishment Labs Holdings Inc
Closed
82,299
$4,189,019,000
Precision BioSciences, Inc.
11.28%
426,293
$4,147,831,000 0.10%
Newamsterdam Pharma Company
Closed
175,000
$4,138,750,000
Skye Bioscience Inc
Opened
500,000
$4,005,000,000 0.10%
Trinity Biotech Plc
No change
1,800,000
$3,834,000,000 0.09%
iRhythm Technologies Inc
85.64%
35,205
$3,789,466,000 0.09%
Lyra Therapeutics, Inc.
No change
12,757,562
$3,533,844,000 0.09%
Biodesix Inc
Opened
2,173,880
$3,326,036,000 0.08%
Envveno Medical Corporation
No change
623,315
$3,272,404,000 0.08%
Foghorn Therapeutics Inc.
Opened
544,000
$3,128,000,000 0.08%
Nanobiotix
No change
555,066
$2,775,330,000 0.07%
Absci Corporation
No change
700,000
$2,156,000,000 0.05%
Spdr Ser Tr
Opened
22,665
$2,101,272,000 0.05%
X4 Pharmaceuticals, Inc.
No change
3,545,454
$2,056,363,000 0.05%
Forte Biosciences, Inc.
No change
3,265,359
$1,753,498,000 0.04%
Revance Therapeutics Inc
No change
600,000
$1,542,000,000 0.04%
Structure Therapeutics Inc
Opened
34,852
$1,368,638,000 0.03%
Fate Therapeutics Inc
Opened
345,575
$1,133,486,000 0.03%
Kyverna Therapeutics Inc
No change
150,000
$1,125,000,000 0.03%
Singular Genomics Systems In
Closed
2,126,893
$1,093,648,000
Kura Oncology Inc
Closed
48,200
$1,028,106,000
Eagle Pharmaceuticals Inc
Opened
173,365
$970,844,000 0.02%
Amylyx Pharmaceuticals Inc
Closed
300,000
$852,000,000
Vbi Vaccines Inc Cda
No change
1,261,710
$832,728,000 0.02%
Tactile Sys Technology Inc
93.06%
62,639
$747,910,000 0.02%
Syros Pharmaceuticals Inc.
No change
116,754
$602,451,000 0.01%
Singular Genomics Systems In
Opened
70,896
$599,071,000 0.01%
Caremax Inc
No change
122,643
$342,174,000 0.01%
Axogen Inc.
98.04%
30,421
$220,248,000 0.01%
No transactions found
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